Lexington Catholic High School is a Roman Catholic high school located in the Rosemill neighborhood in Lexington, Kentucky. It is located in the Roman Catholic Diocese of Lexington. In 2007, it was named a Blue Ribbon School of Excellence.

The Diocese of Lexington is a Latin Church ecclesiastical territory, or diocese, in southeastern Kentucky in the United States. It was erected on January 14, 1988. The diocese is a suffragan in the ecclesiastical province of the metropolitan Archdiocese of Louisville. The Diocese of Lexington provides education for approximately 4,300 students in its 15 elementary schools and two high schools located throughout the diocese, and maintains Newman Centers at eight of Kentucky's colleges and universities.