Lexington Union Station was a union station, serving most of the railroads passing through Lexington, Kentucky. Located on Main Street, just west of Walnut Street it served the Chesapeake and Ohio Railway and the Louisville and Nashville Railroad from 1907 to 1957.

The George Washington was a named passenger train of the Chesapeake and Ohio Railway running between Cincinnati, Ohio and Washington, D.C. that operated from 1932, the 200th anniversary of the birth of George Washington, to 1974. A section divided from the main train at Gordonsville, Virginia and operated through Richmond to Phoebus, Virginia. From the west, a section originated in Louisville and joined at Ashland.