Liège-Guillemins railway station is the main station in Liège, Belgium. It is one of the most important hubs in the country and is one of the four Belgian stations on the high-speed rail network. The station is used by 15,000 people every day, which makes it the eleventh-busiest station in Belgium and the third in Wallonia. It is operated by the National Railway Company of Belgium (SNCB/NMBS).

The HSL 2 is a Belgian high-speed rail line between Leuven and Ans and is 66.2 km (41 mi) long, all of it on dedicated high-speed tracks, which began service on 15 December 2002. As part of the Belgian railway network, it is owned, technically operated and maintained by Infrabel.