The lieutenant governor of Missouri is the first person in the order of succession of the U.S. state of Missouri's executive branch, thus serving as governor in the event of the death, resignation, removal, impeachment, absence from the state, or incapacity due to illness of the governor of Missouri. The lieutenant governor also serves, ex officio, as president of the Missouri Senate. The lieutenant governor is elected separately from the governor, and therefore may be of a different party than the governor.

William Henry Ashley was an American miner, land speculator, manufacturer, territorial militia general, politician, frontiersman, fur trader, entrepreneur, hunter, and slave owner. Ashley was best known for being the co-owner with Andrew Henry of the highly-successful Rocky Mountain Fur Incorporated, otherwise known as "Ashley's Hundred" for the famous mountain men working for the firm from 1822 to 1834.