Lignum vitae is a wood, also called guayacan or guaiacum, and in parts of Europe known as Pockholz or pokhout, from trees of the genus Guaiacum. The trees are indigenous to the Caribbean and the northern coast of South America and have been an important export crop to Europe since the beginning of the 16th century. The wood was once very important for applications requiring a material with its extraordinary combination of strength, toughness, and density. It is also the national tree of the Bahamas, and the Jamaican national flower.

Bulnesia sarmientoi is a tree that inhabits a part of the Gran Chaco area in South America, around the Argentina-Bolivia-Paraguay border. Its wood is often traded as "Paraguay lignum vitae", since it has properties and uses similar to the "true" lignum vitae trees of genus Guaiacum, which are close relatives. Another trade name is "vera" or "verawood", which may also refer to the even more closely related B. arborea. Another common but rather ambiguous name is palo santo, which it shares with the species Bursera graveolens.