Limache is a town and commune in Marga Marga Province, Valparaíso Region, Chile. It is the only Chilean commune with two urban areas: San Francisco de Limache on the north side of the Pelumpén stream, and Limache Viejo on the south. Limache is well-known in Chile for its production of tomatoes, as well as the annual celebration of its patron saint known as the Virgin of the 40 Hours.

The Valparaíso Region is one of Chile's 16 first order administrative divisions. With the country's second-highest population of 1,790,219 as of 2017, and fourth-smallest area of 16,396.1 km2 (6,331 sq mi), the region is Chile's second most densely populated after the Santiago Metropolitan Region to the southeast. The region also includes Chile's remote islands of the Pacific Ocean, including Rapa Nui and the Juan Fernandez Islands.