Limehouse Blues is a 1934 American crime film, directed by Alexander Hall. The film is set in the Limehouse district in the East End of London and its Chinatown. Among the stars of the film were George Raft and Anna May Wong. The film is named after the song "Limehouse Blues".

Limehouse is a district in the London Borough of Tower Hamlets in East London. It is 3.9 miles (6.3 km) east of Charing Cross, on the northern bank of the River Thames. Its proximity to the river has given it a strong maritime character, which it retains through its riverside public houses and steps, such as The Grapes and Limehouse Stairs. It is part of the traditional county of Middlesex. It became part of the ceremonial County of London following the passing of the Local Government Act 1888, and then part of Greater London in 1965.