Line 18 of the Guangzhou Metro is a rapid transit express line in Guangzhou with trains operating up to 160 km/h (99 mph). It will run in a south-north direction, connecting Wanqingsha in Nansha District, Panyu Square in Panyu District, Modiesha in Haizhu District, Zhujiang New Town and Guangzhou East Railway Station in Tianhe District. The line commenced service on 28 September 2021.

The Guangzhou Metro is the rapid transit system of the city of Guangzhou in the Guangdong Province of China. It is operated by the state-owned Guangzhou Metro Corporation and was the fourth metro system to be built in mainland China, after those of Beijing, Tianjin, and Shanghai.