Line 2 of the Dongguan Rail Transit is a rapid transit line in Dongguan. The line currently has 15 stations and is 37.743 kilometres (23.452 mi) long, from Dongguan railway station to Humen railway station. It opened on 27 May 2016. Construction of Line 2 began in 2010.

Dongguan is a prefecture-level city in central Guangdong Province, China. An important industrial city in the Pearl River Delta, Dongguan borders the provincial capital of Guangzhou to the north, Huizhou to the northeast, Shenzhen to the south, and the Pearl River to the west. It is part of the Pearl River Delta built-up area with more than 65.57 million inhabitants as of the 2020 census spread over nine municipalities across an area of 19,870 square kilometers (7,670 sq mi).