Lisle is a town in Broome County, New York, United States. The population was 2,751 at the 2010 census.

U.S. Route 11 (US 11) is a part of the United States Numbered Highway System that runs from New Orleans, Louisiana, to the Canada–United States border at Rouses Point, New York. In the state of New York, US 11 extends for 318.66 miles (512.83 km) from the Pennsylvania state line south of the Southern Tier city of Binghamton to the Canada–United States border at the North Country village of Rouses Point, where it becomes Route 223 upon entering Quebec. The portion of US 11 south of Watertown follows a mostly north–south alignment and is paralleled by Interstate 81 (I-81) while the part of the route north of Watertown follows a more east–west routing, parallel to but not directly on the St. Lawrence River.