Holmes Chapel is a civil parish in Cheshire East, England. It contains eleven buildings that are recorded in the National Heritage List for England as designated listed buildings. Of these, one is listed at Grade I, the highest grade, two are listed at Grade II*, the middle grade, and the others are at Grade II. The parish is occupied by the large village of Holmes Chapel and the surrounding countryside. What is now the Crewe–Manchester railway line passes through the parish, and there are two listed structures associated with this, the Twemlow Viaduct and a nearby boundary post. Also running through the parish is the River Dane, and a bridge crossing it is listed. The other listed buildings are houses, cottages and farmhouses, together with a church and a public house.

Holmes Chapel is a village and civil parish in the unitary authority area of Cheshire East and the ceremonial county of Cheshire, England; until 1974, the parish was known as Church Hulme. It is located about 8 miles (13 km) north of Crewe and 21 miles (34 km) south of Manchester; Swettenham Meadows Nature Reserve lies 2.5 miles (4.0 km) east of the village and Goostrey lies to the north.