Middlewich is a town within the unitary authority of Cheshire East, England. It contains 41 buildings that are recorded in the National Heritage List for England as designated listed buildings. Of these, two are listed at Grade II*, the middle grade, and the others are at Grade II. The history of the area goes back to the Roman era when it was important for the production of salt. The salt industry in the region has continued since then, but it is not reflected in its listed buildings, other than by the canals. The Trent and Mersey Canal was opened in 1777, and the listed buildings associated with it consist of locks, mileposts, and other buildings and structures. The Middlewich Branch of the Shropshire Union Canal dates from 1829, and the listed buildings associated with this include aqueducts, locks, bridges, and a lock keeper's house. Otherwise, the listed buildings in the town are those usually found in towns, including a church with a sundial in the churchyard, houses, shops, a war memorial and a former mill. Outside the town, the area is rural, and the listed buildings include farmhouses and farm buildings.

Moston is a civil parish in Cheshire East, England. It contains 16 buildings that are recorded in the National Heritage List for England as designated listed buildings, all of which are at Grade II. This grade is the lowest of the three gradings given to listed buildings and is applied to "buildings of national importance and special interest". The parish contains the village of Moston Green, but is otherwise mainly rural. The Trent and Mersey Canal runs through the parish, and eight of the listed buildings are associated with it, namely bridges, locks, and mileposts. The other listed buildings are farmhouses, farm buildings, a cottage, a club that was originally a farmhouse, and a turnpike milepost.