This is a list of listed buildings in Sheffield City Centre, covering the S1 postcode district in the City of Sheffield, South Yorkshire, England. The district contains 137 listed buildings that are recorded in the National Heritage List for England. Of these, two are listed at Grade I, the highest of the three grades, 12 are at Grade II*, the middle grade, and the others are at Grade II, the lowest grade.

Sheffield City Centre is a district of the City of Sheffield and is covered partly by the City ward of the City of Sheffield. It includes the area that is within a radius of roughly 0.75 miles (1.2 km) of Sheffield Cathedral and is encircled by the Inner Ring Road, a circular route started in the late 1960s and completed in 2007. As well as the cathedral, buildings in the city centre include the Grade I listed Town Hall, the City Hall and the Winter Gardens. Several areas of the city centre have been designated as quarters. It is home to the city's major business, transport, leisure and cultural attractions.