Little Dixie is a historic 13- to 17-county region along the Missouri River in central Missouri, United States. Its early Anglo-American settlers were largely migrants from the hemp and tobacco districts of Virginia, Kentucky, and Tennessee. They brought enslaved African Americans with them or purchased them as workers in the region. Because Southerners settled there first, the pre-Civil War culture of the region was similar to that of the Upper South. The area was also known as Boonslick country.

Chariton County is a county located in the north-central portion of the U.S. state of Missouri. As of the 2020 census, the population was 7,408. Its county seat is Keytesville. The county was organized November 16, 1820, from part of Howard County and is named for the Chariton River.