Little Dixie is a historic 13- to 17-county region along the Missouri River in central Missouri, United States. Its early Anglo-American settlers were largely migrants from the hemp and tobacco districts of Virginia, Kentucky, and Tennessee. They brought enslaved African Americans with them or purchased them as workers in the region. Because Southerners settled there first, the pre-Civil War culture of the region was similar to that of the Upper South. The area was also known as Boonslick country.

Missouri is a landlocked state in the Midwestern region of the United States. Ranking 21st in land area, it borders Iowa to the north, Illinois, Kentucky and Tennessee to the east, Arkansas to the south and Oklahoma, Kansas, and Nebraska to the west. In the south are the Ozarks, a forested highland, providing timber, minerals, and recreation. The Missouri River, after which the state is named, flows through the center and into the Mississippi River, which makes up the eastern border. With over six million residents, it is the 18th-most populous state of the country. The largest urban areas are St. Louis, Kansas City, Springfield, and Columbia; the capital is Jefferson City.