The Little River is a 105-mile-long (169 km) tributary of the Withlacoochee River in the U.S. state of Georgia. Via the Withlacoochee and the Suwannee River its waters flow to the Gulf of Mexico. The Little River was also known historically as the Ockolocoochee River.

The Withlacoochee River originates in Georgia, northwest of Nashville, Georgia. It flows south through Berrien County where it joins the New River and forms part of the boundary between Berrien and Cook counties. It then flows south into Lowndes County, Georgia. At Troupville, Georgia the Little River joins the Withlacoochee River flows continues to flow south and forms part of the boundary between Lowndes and Brooks counties in Georgia. The river then flows into Florida for 1.34 miles before returning into Georgia for an additional 2.44 miles. It then returns to Florida, forming the northeast boundary of Madison County, Florida and the western boundary of Hamilton County, Florida and eventually merges with the Suwannee at Suwannee River State Park west of Live Oak. The river is 115 miles (185 km) long.