Littleton is a town in Middlesex County, Massachusetts, United States. The population was 10,141 at the 2020 census.

Praying Indian is a 17th-century term referring to Native Americans of New England, New York, Ontario, and Quebec who converted to Christianity either voluntarily or involuntarily. Many groups are referred to by the term, but it is more commonly used for tribes that were organized into villages. The villages were known as praying towns and were established by missionaries such as the Puritan leader John Eliot and Jesuit missionaries who established the St. Regis and Kahnawake and the missions among the Huron in western Ontario.