Llansantffraed (Llansantffraed-juxta-Usk) is a parish in the community of Talybont-on-Usk in Powys, Wales, near Brecon. The benefice of Llansantffraed with Llanrhystud and Llanddeiniol falls within the Diocese of St Davids in the Church in Wales.

Talybont-on-Usk is a village and community in Powys, Wales, in the historic county of Brecknockshire. It lies on both the Caerfanell river and the Monmouthshire and Brecon Canal, about 1 mile (1.6 km) from the River Usk. In 2001, it had a population of 743, reducing to 719 at the 2011 census. The community includes the settlements of Llansantffraed, Scethrog, Aber Village, and Pencelli.