Locust Street is a major historic street in Center City Philadelphia. The street is the location of several prominent Philadelphia-based buildings, historic sights, and high-rise residential locations. It is an east–west street throughout Center City Philadelphia and runs largely parallel to Chestnut Street, another major Center City Philadelphia street.

Center City includes the central business district and central neighborhoods of Philadelphia, Pennsylvania, United States. It comprises the area that made up the City of Philadelphia prior to the Act of Consolidation, 1854, which extended the city borders to be coterminous with Philadelphia County.