Lois Patrice Griffin is a fictional character from the animated television series Family Guy. She is voiced by Alex Borstein and first appeared on television, along with the rest of the Griffin family, in the episode "Death Has a Shadow" on January 31, 1999. Lois was originally created and designed by series creator Seth MacFarlane for a student film called The Life of Larry in 1995.

"Death Has a Shadow" is the series premiere and the first episode of the first season of the American animated television series Family Guy. Written by series creator Seth MacFarlane and directed by Peter Shin, the episode aired as a sneak peek on the Fox network in the United States on January 31, 1999, following Super Bowl XXXIII. In this episode, Peter loses his job after drinking too much at a stag party, causing him to fall asleep at work. He signs up for welfare to keep his wife Lois from finding out but gets much more money than he expected. After spending his money foolishly, Lois finds out and Peter decides to dump it from a blimp at the Super Bowl. He is arrested for welfare fraud and must await his family's rescue, as well as various performers who would later serve as frequent recurring and guest voices on the series.