Lois Lane is a fictional character on the television series Smallville; she was portrayed continually by Erica Durance since her first appearance in the season four premier "Crusade" to the series finale. Durance began as a guest star in season four but was promoted to series regular status beginning in season five. The character of Lois Lane, first created for comic books by Jerry Siegel and Joe Shuster in 1938 to be the love interest for Clark Kent and his alter-ego Superman, was adapted to television in 2001 by Alfred Gough and Miles Millar - this is the fourth time the character has been adapted into a live-action television series.

Smallville is an American superhero television series developed by writer-producers Alfred Gough and Miles Millar, based on the DC Comics character Superman created by Jerry Siegel and Joe Shuster. The series was produced by Millar/Gough Ink, Tollin/Robbins Productions, DC Comics and Warner Bros. Television. Initially broadcast by the WB, the show premiered on October 16, 2001. After its fifth season, the WB and UPN merged to form The CW, the series' later United States broadcaster until its tenth and final season ended on May 13, 2011.