Lone Mountain is a neighborhood and a historic hill in west-central San Francisco, California. It is the present site of the northern half of the University of San Francisco's main campus. It was once the location of the Lone Mountain Cemetery, a complex encompassing the Laurel Hill, Calvary, Masonic and Odd Fellows Cemeteries.

The University of San Francisco (USF) is a private Jesuit university in San Francisco, California. The university's main campus is located on a 55-acre (22 ha) setting between the Golden Gate Bridge and Golden Gate Park. The main campus is nicknamed "The Hilltop" and is split into two sections within a block of each other. Part of the main campus is located on Lone Mountain, one of San Francisco's major geographical features. Its close historical ties with the City and County of San Francisco are reflected in the university's traditional motto, Pro Urbe et Universitate.