Lonoke is the second most populous city in Lonoke County, Arkansas, United States, and serves as its county seat. According to 2010 United States Census, the population of the city is 4,245. It is part of the Little Rock–North Little Rock–Conway Metropolitan Statistical Area.

Lonoke County is located in the Central Arkansas region of the U.S. state of Arkansas. As of the 2020 census, the population was 74,015, making it the 10th-most populous of Arkansas's 75 counties. The county seat is Lonoke and largest city is Cabot. Included in the Central Arkansas metropolitan area, with Little Rock as the principal city, it is an alcohol prohibition or dry county.