Lonsdale Street is a main street and thoroughfare in the Melbourne central business district, Australia. It runs roughly east–west and was laid out in 1837 as one of Melbourne's original boundaries within the Hoddle Grid. The street extends from Spring Street in the east to Spencer Street in the west.

The Hoddle Grid is the contemporary name given to the approximately 1-by-0.5-mile grid of streets that form the Melbourne central business district, Australia. Bounded by Flinders Street, Spring Street, La Trobe Street, and Spencer Street, it lies at an angle to the rest of the Melbourne suburban grid, and so is easily recognisable. It is named after the surveyor Robert Hoddle, who marked it out in 1837, establishing the first formal town plan. This grid of streets, laid out when there were only a few hundred settlers, became the nucleus for what is now Melbourne, a city of over five million people.