Lopez Tonight is an American late-night television talk show that was hosted by the comedian George Lopez. The hour-long program premiered on November 9, 2009, on cable network TBS. Lopez was the first Mexican-American to host a late-night talk show on an English-language network in the United States. The show featured audience interaction using a high-energy format. The program aired Monday through Thursday at midnight Eastern and Pacific, immediately following Conan. On August 10, 2011, TBS announced that Lopez Tonight would be canceled. The final episode aired two days later on August 12, 2011.

George Edward Lopez is an American stand-up comedian and actor. He is most known for starring in his self-produced ABC sitcom. His stand-up comedy examines race and ethnic relations, including Mexican American culture. Lopez has received several honors for his work and contributions to the Latino community, including the 2003 Imagen Vision Award, the 2003 Latino Spirit Award for Excellence in Television and the National Hispanic Media Coalition Impact Award. He was also named one of "The Top 25 Hispanics in America" by Time magazine in 2005.