Lords of St. Thomas is a 2018 historical novel by American writer Jackson Ellis. The novel won the inaugural Howard Frank Mosher Book Prize in 2017, selected by Howard Frank Mosher himself shortly before his death in January 2017.

St. Thomas, Nevada is a ghost town in Clark County, Nevada, United States, near where the Muddy River flows into the Colorado River. St. Thomas was purchased by the US Federal Government and abandoned as the waters of Lake Mead submerged the town in the 1930s.