Lorenzo is a city in Crosby County, Texas, United States. As of the 2010 census, the city population was 1,147, down from 1,372 in 2000. It is part of the Lubbock Metropolitan Statistical Area.

Crosby County is a county located in the U.S. state of Texas. As of the 2020 census, its population was 5,133. The county seat is Crosbyton. The county was founded in 1876 and later organized in 1886. Both the county and its seat are named for Stephen Crosby, a land commissioner in Texas.