Loretto is a borough in Cambria County, Pennsylvania, United States. As of the 2010 census it had a population of 1,302. Like the rest of Cambria County, it is part of the Johnstown, Pennsylvania, Metropolitan Statistical Area. Loretto is the home of Saint Francis University.

The Federal Correctional Institution, Loretto is a low-security United States federal prison for male inmates in Pennsylvania. An adjacent satellite prison camp houses minimum-security male offenders. It is operated by the Federal Bureau of Prisons, a division of the United States Department of Justice.