Lost Highway is the soundtrack album for the 1997 David Lynch film of the same name. It was produced by Trent Reznor of Nine Inch Nails, and includes original music from the film recorded by Reznor, Angelo Badalamenti and Barry Adamson, as well as songs by other artists used in the film. The album reached No. 7 on the Billboard 200 and reached Gold status in the United States and Platinum in Canada. The album was re-released on vinyl in November 2016 by Dutch label Music On Vinyl.

Lost Highway is a 1997 surrealist neo noir film directed by David Lynch and co-written by Lynch and Barry Gifford. It stars Bill Pullman, Patricia Arquette, Balthazar Getty, and Robert Blake in his final film role. The film follows a musician (Pullman) who begins receiving mysterious VHS tapes of him and his wife (Arquette) in their home. He is suddenly convicted of murder, after which he inexplicably disappears and is replaced by a young mechanic (Getty) leading a different life.