A lost comet is one which was not detected during its most recent perihelion passage. This generally happens when data is insufficient to reliably calculate the comet's location or if the solar elongation is unfavorable near perihelion passage. The D/ designation is used for a periodic comet that no longer exists or is deemed to have disappeared.

D/1770 L1, popularly known as Lexell's Comet after its orbit computer Anders Johan Lexell, was a comet discovered by astronomer Charles Messier in June 1770. It is notable for having passed closer to Earth than any other comet in recorded history, approaching to a distance of only 0.015 astronomical units, or six times the distance from the Earth to the Moon. The comet has not been seen since 1770 and is considered a lost comet.