Lostwithiel railway station serves the town of Lostwithiel in Cornwall, England. It is 277 miles 36 chains from the zero point at London Paddington measured via Box and Plymouth Millbay. Great Western Railway operates the station along with every other station in Cornwall.

Lostwithiel is a civil parish and small town in Cornwall, England, United Kingdom at the head of the estuary of the River Fowey. According to the 2001 census it had a population of 2,739, increasing to 2,899 at the 2011 census. The Lostwithiel electoral ward had a population of 4,639 at the 2011 census. The name Lostwithiel comes from the Cornish "lostwydhyel" which means "tail of a wooded area".