Louis de Gonzague, Duke of Nevers was a soldier, governor and statesman during the French Wars of Religion. His father and brother were reigning dukes of Mantua. He came to France in 1549, and fought for Henri II of France during the latter Italian Wars, getting himself captured during the battle of Saint Quentin. Due to his Italian connections he was seen as a useful figure to have as governor of French Piedmont, a post he would hold until Henri III ceded the territory in 1574. In 1565 his patron, Catherine de' Medici secured for him a marriage with the key heiress Henriette de Clèves, elevating him to duke of Nevers and count of Rethel. He fought for the crown through the early wars of religion, receiving a bad injury in the third war. At this time he formed a close bond with the young Anjou, future king Henri III, a bond that would last until the king's death.

Henriette de La Marck, also known as Henriette of Cleves, was a French noblewoman and courtier. She was the 4th Duchess of Nevers, suo jure Countess of Rethel, and Princess of Mantua by her marriage with Louis I of Gonzaga-Nevers. A very talented landowner, she was one of France's chief creditors until her death.