Louisa Catherine Adams was the first lady of the United States from 1825 to 1829 during the presidency of John Quincy Adams. She was born in England and raised in France. Her father was an influential American merchant, and she was regularly introduced to prominent Americans. After her family returned to England, she met John Quincy Adams in 1795, and the two began a tenuous courtship. They were wed in 1797 after a year of engagement, beginning a marriage of disagreements and personality conflicts. She joined her husband on his diplomatic mission to Prussia, where she was popular with the Prussian court. When they returned to the United States, her husband became a senator and she gave birth to three sons. John was appointed minister to the Russian Empire in 1809, and they traveled to Russia without their two older sons, against Louisa's wishes. Though she was again popular with the court, she detested living in Russia, especially after the death of her infant daughter in 1812. She lived in Russia alone for a year while John negotiated the Treaty of Ghent, and when he asked her to join him in 1815, she made the dangerous 40 day journey across war-torn Europe.

John Quincy Adams was an American statesman, politician, diplomat, lawyer, and diarist who served as the sixth president of the United States, from 1825 to 1829. He previously served as the eighth United States secretary of state from 1817 to 1825. During his long diplomatic and political career, Adams served as an ambassador and also as a member of the United States Congress representing Massachusetts in both chambers. He was the eldest son of John Adams, who served as the second president of the United States from 1797 to 1801, and First Lady Abigail Adams. Initially a Federalist like his father, he won election to the presidency as a member of the Democratic-Republican Party, and later, in the mid-1830s, became affiliated with the Whig Party.