The Louisville metropolitan area is the 43rd largest metropolitan statistical area (MSA) in the United States. It had a population of 1,395,855 in 2020 according to the latest official census, and its principal city is Louisville, Kentucky.

Louisville is the most populous city in the Commonwealth of Kentucky, sixth-most populous city in the Southeast, and the 27th-most-populous city in the United States. By land area, it is the country's 24th-largest city, although by population density, it is the 265th most dense city. Louisville is the historical county seat and, since 2003, the nominal seat of Jefferson County, on the Indiana border.