The Lower Brulé Indian Reservation is an Indian reservation that belongs to the Lower Brulé Lakota Tribe. It is located on the west bank of the Missouri River in Lyman and Stanley counties in central South Dakota in the United States. It is adjacent to the Crow Creek Indian Reservation on the east bank of the river. The Kul Wicasa Oyate, the Lower Brulé Sioux, are members of the Sicangu, one of the bands of the Lakota Tribe. Tribal headquarters is in Lower Brule.

The Brulé are one of the seven branches or bands of the Teton (Titonwan) Lakota American Indian people. They are known as Sičhą́ǧu Oyáte —Sicangu Oyate—, Sicangu Lakota, or "Burnt Thighs Nation". Learning the meaning of their name, the French called them the Brûlé. The name may have derived from an incident where they were fleeing through a grass fire on the plains.