Lower Saranac Lake is one of three connected lakes, part of the Saranac River, near the village of Saranac Lake in the Adirondacks in northern New York. With Middle Saranac Lake and Upper Saranac Lake, a 17-mile (27 km) paddle with only one portage is possible. The Saranac Lake Islands Public Campground provides 87 campsites on inlands in Lower and Middle Saranac Lake. In addition to the Saranac River, it is fed by nearby Lake Colby, Fish Creek, and Lilly Pad Pond. Lower Saranac Lake is located in the town of Harrietstown, New York. The lake, along with both Upper and Middle Saranac Lakes, is also part of the 740-mile Northern Forest Canoe Trail, which begins in Old Forge, NY and ends in Fort Kent, ME.

The Trudeau Institute is an independent, not-for-profit, biomedical research center located on a 42 acres (170,000 m2) campus in Saranac Lake, New York. Its scientific mission is to make breakthrough discoveries that lead to improved human health.