Lowitja O'Donoghue, also known as Lois O'Donoghue and Lois Smart, was an Australian public administrator and Indigenous rights advocate. She was the inaugural chairperson of the Aboriginal and Torres Strait Islander Commission (ATSIC) from 1990 to 1996. She is known for her work in improving the health and welfare of Indigenous Australians, and also for the part she played in the drafting of the Native Title Act 1993, which established native title in Australia.

The Aboriginal and Torres Strait Islander Commission (ATSIC) (1990–2005) was the Australian Government body through which Aboriginal Australians and Torres Strait Islanders were formally involved in the processes of government affecting their lives, established under the Hawke government in 1990. A number of Indigenous programs and organisations fell under the overall umbrella of ATSIC.