Lows Lake is located in the Adirondack Park in northeastern New York. It is in the New York State Forest Preserve Five Ponds Wilderness Area, 10 miles (16 km) southwest of Tupper Lake. The Adirondack Park Agency classifies the lake as a Primitive Area meaning that it is wilderness in character, but contains artificial structures and private lands.

The Five Ponds Wilderness Area, an Adirondack Park unit of New York's Forest Preserve, is located in the towns of Fine and Clifton in St. Lawrence County, the town of Webb in Herkimer County and the town of Long Lake in Hamilton County. It includes 1,064 acres (4.3 km2) of private inholdings, 99 bodies of water covering 1,964 acres (7.9 km2), 57.9 miles (93.2 km) of trails, and 14 lean-tos.