The Loxton railway line is a closed railway line in the northern Murray Mallee region of South Australia. It ran north-east from Tailem Bend to grain silos near Loxton.

The Murray Mallee is the grain-growing and sheep-farming area of South Australia. It is bounded to the north and west by the Murray River, called the "River Murray" in South Australia, to the east by the Victorian border, and extending about 50 km south of the Mallee Highway.