Lucedale is a city in George County, Mississippi, United States. It is part of the Pascagoula, Mississippi Metropolitan Statistical Area. The population was 2,923 at the 2010 census, up from 2,458 at the 2000 census. It is the county seat of George County.

Eric Shannon Moulds is an American former professional football player who was a wide receiver for 12 seasons in the National Football League (NFL). He played college football for Mississippi State University and was drafted by the Buffalo Bills 24th overall in the 1996 NFL draft. In 2009, Moulds was one of three receivers named to the Buffalo Bills 50th Anniversary All-Time Team.