Lucedale is a city in George County, Mississippi, United States. It is part of the Pascagoula, Mississippi Metropolitan Statistical Area. The population was 2,923 at the 2010 census, up from 2,458 at the 2000 census. It is the county seat of George County.

George County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 24,350. Its county seat is Lucedale. The county is named for James Z. George, US Senator from Mississippi. George County was included in the Pascagoula, MS Metropolitan Statistical Area. The county is located adjacent to the Alabama state line.