Charles "Lucky" Luciano was an Italian-born gangster who operated mainly in the United States. He started his criminal career in the Five Points Gang and was instrumental in the development of the National Crime Syndicate. Luciano is considered the father of modern organized crime in the United States for the establishment of the Commission in 1931, after he abolished the boss of bosses title held by Salvatore Maranzano following the Castellammarese War. He was also the first official boss of the modern Genovese crime family.

Salvatore Maranzano, nicknamed Little Caesar, was an Italian-American mobster from the town of Castellammare del Golfo, Sicily, and an early Cosa Nostra boss who led what later would become the Bonanno crime family in New York City. He instigated the Castellammarese War in 1930 to seize control of the American Mafia, winning the war after the murder of rival faction head Joe Masseria in April 1931. He then briefly became the Mafia's capo di tutti capi and formed the Five Families in New York City, but was murdered on September 10, 1931, on the orders of Charles "Lucky" Luciano, who established The Commission, in which families shared power to prevent future turf wars.