The Ludlow Street Jail was New York City's Federal prison, located on Ludlow Street and Broome Street in Manhattan. Some prisoners, such as soldiers, were held there temporarily awaiting extradition to other jurisdictions, but most of the inmates were debtors imprisoned by their creditors. Seward Park Campus now sits on the site of the jail.

Ludlow Street runs between Houston and Division Streets on the Lower East Side of Manhattan in New York City. Vehicular traffic runs south on this one-way street.