Luisa María Francisca de Guzmán y Sandoval was Queen of Portugal as the spouse of King John IV, the first Braganza ruler. She was the mother of two kings of Portugal and a queen of England. She served as regent of Portugal from 1656 until 1662.

John IV, nicknamed John the Restorer, was the King of Portugal whose reign, lasting from 1640 until his death, began the Portuguese restoration of independence from Habsburg Spanish rule. His accession established the House of Braganza on the Portuguese throne, and marked the end of the 60-year-old Iberian Union by which Portugal and Spain shared the same monarch.