Luke is a town in Allegany County, Maryland, United States, located along the Potomac River just upstream of Westernport. Known originally as West Piedmont, the town is part of the Cumberland, MD-WV Metropolitan Statistical Area. The population was 85 as of the 2020 census.

Allegany County is located in the northwestern part of the U.S. state of Maryland. As of the 2020 census, the population was 68,106. Its county seat is Cumberland. The name Allegany may come from a local Lenape word, welhik hane or oolikhanna, which means 'best flowing river of the hills' or 'beautiful stream'. A number of counties and a river in the Appalachian region of the U.S. are named Allegany, Allegheny, or Alleghany. Allegany County is part of the Cumberland metropolitan area. It is a part of the Western Maryland "panhandle".