Luke Spencer is a fictional character in the American television soap opera General Hospital, played by Anthony Geary from 1978 until his departure in July 2015. Geary holds the record for most Daytime Emmy wins for Outstanding Lead Actor in a Drama Series for his work as Luke. He was the show's fifth most tenured character after Monica Quartermaine, Laura Spencer, Scott Baldwin, and Bobbie Spencer.

General Hospital is an American daytime television soap opera. It is listed in Guinness World Records as the longest-running American soap opera in production, and the second in American history after Guiding Light. Concurrently, it is the world's third longest-running scripted drama series in production after British serials The Archers and Coronation Street, as well as the world's second-longest-running televised soap opera still in production. General Hospital premiered on the ABC television network on April 1, 1963. General Hospital is the longest-running serial produced in Hollywood, and the longest-running entertainment program in ABC television history. It holds the record for most Daytime Emmy Awards for Daytime Emmy Award for Outstanding Drama Series, with 14 wins.