Lusambo is the capital city of Sankuru province, Democratic Republic of the Congo. The town lies north of the confluence of the Sankuru River and the Lubi River. Lusambo is served by Lusambo Airport.

Sankuru is one of the 21 new provinces of the Democratic Republic of the Congo created in the 2015 repartitioning. Sankuru, Kasaï-Oriental, and Lomami provinces are the result of the dismemberment of the former Kasaï-Oriental province. Sankuru was formed from the Sankuru District whose town of Lusambo was elevated to capital city of the new province.