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Chandra Mohana

Chandra Mohana known as Samooga Thondu is a 1936 Indian Tamil-language film directed by Raja Chandrasekhar. The film stars M. K. T. N. Meenakshi in the lead roles, it marks the cinematic debut of Kothamangalam Subbu. Chandra Mohan is a social activist in love with a young woman Mohana; the couple face numerous problems due to the plans of a mill manager. M. K. Radha as Chandra Mohan S. V. Venkataraman as Kamalanathan T. N. Meenakshi as Mohana K. P. Kamakshi K. R. Jayalakshmi as the dancer ‘Clown’ M. S. Sundaram S. M. Subramaniam P. R. MangalamDanceRagini Devi The film marked the cinematic debut of writer and filmmaker Kothamangalam Subbu, who wrote the film's story while M. Kandaswami Mudaliar wrote the dialogues, it was directed by Raja Chandrasekhar, produced by the Madurai-based Mohan Movietone. Shooting took place at the Bombay-based Film City Studios; the film had Samooga Thondu. There is no known information on the film's music lyricist. A reviewer for Malaya Tribune positively reviewed the film for the performances of the cast.

The film was an average success

Cromoglicic acid

Cromoglicic acid is traditionally described as a mast cell stabilizer, is marketed as the sodium salt sodium cromoglicate or cromolyn sodium. This drug prevents the release of inflammatory chemicals such as histamine from mast cells. Cromoglicic acid has been the non-corticosteroid treatment of choice in the treatment of asthma, for which it has been replaced by leukotriene receptor antagonists because of their convenience. Cromoglicic acid requires administration four times daily, does not provide additive benefit in combination with inhaled corticosteroids. Cromolyn sodium was discovered in 1965 by Roger Altounyan, himself a lifelong asthma sufferer, it is considered a breakthrough drug in management of asthma, as the patients can be freed from steroids in many cases. Altounyan was investigating certain herbs which have bronchodilating properties. One such plant was khella, used as a muscle relaxant since ancient times in Egypt. Altounyan deliberately inhaled derivatives of the active ingredient khellin to determine if they could block his asthma attacks.

After several years of trial he isolated an effective and safe asthma-preventing compound called cromolyn sodium. Cromoglicic acid is available in multiple forms: as a nasal spray to treat allergic rhinitis. in a nebulizer solution for aerosol administration to treat asthma. as an inhaler for preventive management of asthma. The maker of Intal, King Pharmaceuticals, has discontinued manufacturing the inhaled form, cromolyn sodium inhalation aerosol, due to issues involving CFC-free propellant; as stocks are depleted, this inhaler preparation will no longer be available to patients. In the EU it is manufactured without CFCs by Sanofi, although it must be imported from Canada for USA residents; as eye drops for allergic conjunctivitis in an oral form to treat mastocytosis, mast cell activation syndrome, dermatographic urticaria and ulcerative colitis. Another oral product, Intercron, is used for food allergies. "Cromolyn works because it prevents the release of mediators that would attract inflammatory cells and because it stabilizes the inflammatory cells.

MCT mast cells found in the mucosa are stabilised." Nedocromil is another mast cell stabilizer that works in controlling asthma. The underlying mechanism of action is not understood. Pharmaceutical companies have produced 20 related compounds that are or more potent at stabilising mast cells and none of them have shown any anti-asthmatic effect, it is more that these work by inhibiting the response of sensory C fibers to the irritant capsaicin, inhibiting local axon reflexes involved in asthma, may inhibit the release of preformed T cell cytokines and mediators involved in asthma. It is known to somewhat inhibit chloride channels and thus may inhibit the: exaggerated neuronal reflexes triggered by stimulation of irritant receptors on sensory nerve endings release of preformed cytokines from several type of inflammatory cells in allergen-induced asthmaNote: Another chemical was shown, in the same study, to be a more effective chloride channel blocker, it may act by inhibiting calcium influx. Cromoglicate is classified as a chromone.

Cromolyn is being tested as a drug to treat insulin-induced lipoatrophy. Cromolyn is known to bind S100P protein and disrupt the interaction with RAGE