Luzerne is an unincorporated community in Oscoda County in the U.S. state of Michigan. The community is located within Big Creek Township. As an unincorporated community, Luzerne has no legally defined boundaries or population statistics of its own but does have its own post office with the 48636 ZIP Code.

Oscoda County is a county in the U.S. state of Michigan. As of the 2020 census, the population was 8,219, making it the least populous county in the Lower Peninsula, and the sixth-least populous county in the entire state. The county seat is Mio, an unincorporated community near the center of the county.