Luzerne is an unincorporated community in Oscoda County in the U.S. state of Michigan. The community is located within Big Creek Township. As an unincorporated community, Luzerne has no legally defined boundaries or population statistics of its own but does have its own post office with the 48636 ZIP Code.

M-72 is a state trunkline highway in the US state of Michigan, running from Lake Huron to Lake Michigan across the northern part of the Lower Peninsula. The highway connects M-22 in Empire with US Highway 23 (US 23) in Harrisville. It is one of only three Michigan state trunklines that cross the Lower Peninsula, shore to shore. In between, M-72 runs across Northern Michigan woodland, agricultural areas of the Leelanau Peninsula near Traverse City, and the Au Sable River watershed. The trunkline also provides access to Camp Grayling, a National Guard training facility near the city of the same name. Traffic levels along the highway vary from approximately 800 vehicles a day on the east end to over 32,000 vehicles near Traverse City.