The Lyon–Geneva railway is an important route in the national rail network. It connects not only Geneva but also feeds the Maurienne railway and the Geneva to Valence via Grenoble line. It carries a variety of traffic: TGV Paris-Geneva, Geneva - South of France, TER Auvergne-Rhône-Alpes, Léman Express and goods trains.

Lyon-Jean Macé station is a railway station in the 7th arrondissement of Lyon. It is situated on the Paris–Marseille railway and the Lyon–Geneva railway. The station is a part of the Lyon urban area rapid transit network. It was aimed to decongest the major stations Part-Dieu and Perrache while allowing access to the public transport of Lyon (TCL). The station began operation on 13 December 2009.