Lyon-Perrache is a large railway station located in the Perrache district, in the 2nd arrondissement of Lyon, France. The station was opened in 1857 and is located on the Paris–Marseille railway, Lyon–Geneva railway and Moret–Lyon railway. The train services are operated by SNCF and include TGV, Intercity and local services.

The Lyon–Geneva railway is an important route in the national rail network. It connects not only Geneva but also feeds the Maurienne railway and the Geneva to Valence via Grenoble line. It carries a variety of traffic: TGV Paris-Geneva, Geneva - South of France, TER Auvergne-Rhône-Alpes, Léman Express and goods trains.