Lyon-Perrache is a large railway station located in the Perrache district, in the 2nd arrondissement of Lyon, France. The station was opened in 1857 and is located on the Paris–Marseille railway, Lyon–Geneva railway and Moret–Lyon railway. The train services are operated by SNCF and include TGV, Intercity and local services.

The LGV Sud-Est is a French high-speed rail line which connects the Paris and Lyon areas. It was France's first high-speed rail line. The inauguration of the first section between Saint-Florentin and Sathonay-Camp by President François Mitterrand on 22 September 1981 marked the beginning of the re-invigoration of French passenger rail service.