Lyon-Perrache is a large railway station located in the Perrache district, in the 2nd arrondissement of Lyon, France. The station was opened in 1857 and is located on the Paris–Marseille railway, Lyon–Geneva railway and Moret–Lyon railway. The train services are operated by SNCF and include TGV, Intercity and local services.

The railway from Paris to Marseille is an 862-kilometre long railway line, that connects Paris to the southern port city of Marseille, France, via Dijon and Lyon. The railway was opened in several stages between 1847 and 1856, when the final section through Lyon was opened. The opening of the LGV Sud-Est high speed line from Paris to Lyon in 1981, the LGV Rhône-Alpes in 1992 and the LGV Méditerranée in 2001 has decreased its importance for passenger traffic.